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About PharmaTech International
PharmaTech is the world leader in industrial prostaglandin API synthesis. Corey lactone based processes and two/three component coupling addition processes are scaled up to afford multi-kilo amounts of target prostaglandin products. We do not depend on advance intermediate outsourcing and will react quickly to your API or prostaglandin intermediate needs. Since the inception of our company we have accumulated expert knowledge in all areas of synthetic chemistry and scale-up. Combined, we have over 100 years of complex synthesis experience. This expertise is the key to providing you with fast and reliable service, more economically than our competition. Our API Manufacturing Division, in addition to PG API's, offers a number of intermediates and building blocks in both prostaglandin and non-prostaglandin areas. We are frequently the only manufacturer in the world willing to contract the synthesis of the most complex and unstable molecules.
Company Profile

We have the expertise and resources to deliver - on time, to specification, again and again. Whatever the scale, be it first development quantities or large commercial volumes; whatever the molecule, whether it is active ingredient, key intermediate or starting material; and whatever the technical challenges and processes involved - PharmaTech will deliver.

Our chemists are experts in complex, multi-step syntheses utilizing a wide variety of chemistries and isolation techniques. The Fairfield Plant uses dedicated reactor suites. Reactors are glass, glass-lined steel or specialty metal construction. The suites contain reactors with volumes >1000L, 600L, 400L, 200L/ larger reactors are planned for installation. In addition number of mobile reactors (10-50 gallons) are in the kilo labs to prepare intermediate quantities of products. Equipment includes Buchi ChemReactors CR161 (-90C) and CR251 (-60C), 20/100L Buchi evaporators, Pope's 6' wiped film evaporator, high pressure hydrogenators, ultra low temperature reactors, Varian Preparative Scale HPLC System, industrial scale Biotage Flash Chromatography, Buchi 100L enclosed filtration unit, Aurora Filter System and number of other specialized equipment.

In house chemical information system provides on line access to the majority of ACS journals, ACS archives, STN International, Delphion Intelectual Property Network, and number of other databases. Chemical library offers an extensive inventory of periodicals, monographs and encyclopedic works in all areas of organic/ synthetic chemistry and technology.

Chemical development, scale-up and manufacturing have extensive, state of the art analytical support.

Organic Specialties
  • Prostaglandin Chemistry
  • Asymmetric Synthesis/ Chiral Resolutions/ Enzymatic Catalysis
  • High Pressure Synthesis
  • Low Temperature Reactions to -110 C
  • Organometallic Synthesis/ Grignard/ Heck/ Cuprate/ Wurtz
  • Ozonolysis
  • Diazomethane/ Phosgenation
  • Heterocyclic Synthesis/ Diels-Alder/ C-C Coupling Reactions
  • Specialized Reductions
  • Rare Amino Acids Chemistry
Instrumentation
Jeol High Resolution 270 MHZ NMR Spectrometer (C; H; N; O; P; Si probes)/ Hewlett-Packard MS Engine Mass Spectrometer (GS/MS Direct Probe Insertion and Auto Sampler) (Detection- Chemical Ionization/Electron Ionization) High Pressure Liquid Chromatography with photodiode array detection and data processing /LCMS/ UV Spectrophotometers / high resolution FT-IR Spectroscopy/ Elemental Analysis/ TLC with automated sample application and densitometric quantitation / Digital Polarimetry