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The chemistry and development
expertise of Pharmatech complements our manufacturing capabilities,
offering customers a single source for specialty chemical solutions.
Phamatech International Inc. manufactures organic intermediates, custom
products and cGMP active pharmaceutical ingredients (APIs) for
pharmaceutical and industrial companies around the world. Our chemists are
experts in complex, multi-step syntheses utilizing a wide variety of
chemistries. We have developed over thousand processes in-house.
Affiliated production facilities with reactors to 2,000 gallons produce
intermediates in multi-ton quantities. For projects requiring development,
our kilo lab chemists can develop commercially feasible manufacturing
processes or improve customer-provided chemistries. Reaction calorimeters
ensure safe and efficient scale-up as processes advance to pilot and
commercial production. Analytical services include reference standard generation, analytical methods development/ validation as well as accelerated and long-term
stability testing.
| | | | Pharmaceutical Intermediates | | | |
Pharmatech customers are requesting
more complex chemistries and shorter delivery schedules. Inquiries at
Pharmatech's Contract Manufacturing Division are shifting from six- or
seven-step synthesis to requests for 18- to 20 step synthetic procedures.
Many times our experience and capabilities allow us to streamline
manufacturing processes, or produce entire synthetic routes, saving our
customers both time and money. Extensive starting-material inventories can jump-start
production on your project. Access to thousands compounds assures rapid
production of products.
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The following list is an example of
selected synthesis capabilities of special interest to our pharmaceutical
and industrial customers.
| | | | - Acylation
- Alkylation
- Amidation
- Amination
- Ammonolysis
- Aryl coupling
- Brominations
- Buchwald reaction
- Chlorinations
- Chloromethylation
- Chiorosulfonation
- Condensation
- Cyanoethylation
- Dealkylation
- Dehalogenation
- Dehydrohalogenation
- Diels Alder reaction
- Enzymatic resolution
- Epoxidation
- Esterification
- Etherification
- Ethylene oxide chemistry
- Fischer Indole synthesis
- Formylation
- Friedel Crafts reaction
- Grignard reaction
- Halide exchange
- Halogenation (Bromination, Chlorination, lodination)
- Hartwig reaction
- Heck reactions
- High pressure reactions (up to 100 bar)
- Heck reactions
- High pressure reactions (up to 100 bar)
- Hydrogenation (up to 100 bar)
- Hydrohalogenation
- Hydrolysis
- Isomerization
- Methyl mercaptan chemistry
- Nitration
- Nucleophilic substitution
- Optical racemization
- Optical resolution
- Organometallic reaction (n-BuLi, NaH, LDA)
- Oxidation (air, hydrogen peroxide, sodium hypochlorite, peracids)
- Ozonolysis Phase transfer reactions
- Phosgenation (with phosgene, diphosgene, and triphosgene)
- Polymerization Quaternization Reduction (Zn/HCI, Na, NaBH4, LiAIH4,
Vitride, etc.)
- Reductive Amination (including stereoselective synthesis)
- Rosenmund reaction
- Sandmeyer reaction
- Saponification
- Silylation
- Sodium cyanide chemistry
- Sonogashira reaction
- Strecker synthesis
- Suzuki coupling
- Swern oxidation
- Transesterification
- Wittig reaction
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